Kuttel, Michelle M. and Timol, Zaheer and Ravenscroft, Neil (2017) Cross protection in Neisseria meningitides serogroups Y and W polysaccharides: a comparative conformational analysis., Carbohydrate Research, 446, 40-47, Elsevier.
Full text not available from this repository. (Use alternate locations listed below)Abstract
The capsular polysaccharide is the main virulence factor in meningococcus. The capsular polysaccharides for meningococcal serogroups Y andWare almost identical polymers of hexose-sialic acid, suggesting the possibility of cross-protection between group Y and W vaccines. However, early studies indicated that they elicit different levels of cross-protection. Here we explore the conformations of the meningococcal Y and W polysaccharides with molecular dynamics simulations of three repeating unit oligosaccharide strands. We find differences in Y and W antigen conformation: the Y polysaccharide has a single dominant conformation, whereas W exhibits a family of conformations including the Y conformation. This result is supported by our NMR NOESY analysis, which indicates key close contacts forWthat are notpresent in Y. These conformational differences provide an explanation for the different levels of cross protection measured for the Y and W monovalent vaccines and the high group W responses observed in HibMenCY-TT vaccinees.
| Item Type: | Journal article (paginated) |
|---|---|
| Uncontrolled Keywords: | Neisseria meningitidis Meningococcus Capsular polysaccharide Carbohydrate antigens Molecular modelling Cross-protection |
| Subjects: | Applied computing > Life and medical sciences Computing methodologies > Modeling and simulation |
| Date Deposited: | 23 Nov 2017 |
| Last Modified: | 10 Oct 2019 15:31 |
| URI: | http://pubs.cs.uct.ac.za/id/eprint/1212 |
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